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In these languages, words beginning in a vowel, like the English word at, are impossible. Other things being equal, longer development times reduce innovation incentives. When more than one drug is exposed to the same surface, leaving seemingly unnoticeable traces of residues, the issue of cross-contamination arises. Since 2006, there's been a long debate whether the anti-drug law goes against the Constitution and principle of personal freedom. However, the idea of attenuating a virus through serial passage still holds.

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