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A pyrogen is a substance that induces fever. Needle-exchange programmes can be traced back to informal activities undertaken during the 1970s. People had developed some antibodies to these and other diseases from the Eurasian continent. Because of this, in the mid-1970s, Japanese drug dealers began to replace sulfuric acid with hydrochloric acid during processing, inadvertently creating solid methamphetamine hydrochloride, or crystal meth.
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