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This clinical description is quite similar to those found in modern textbooks, and it reflected the extent of medical knowledge through the Middle Ages into the 19th century. They are being replaced by acellular vaccines, composed of purified surface antigens, mainly fimbriae, filamentous haemaglutinin, pertactin and pertussis toxin. A form was distinguished by being shared by all its members, the young inheriting any variations they might have from their parents. The tenement was extended by a north wing, moving the garden to the back of the property. This importance becomes especially apparent when considering that much of Singapore's water supply comes from Malaysia.

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